Which of the following is NOT a disadvantage of intravenous antibiotics?

The choice indicating that "Requires compliance" is not a disadvantage of intravenous antibiotics aligns with the context of how IV antibiotics are administered. Compliance generally refers to a patient’s adherence to prescribed treatment regimens, which is more relevant to oral medications, where patients must remember to take their doses regularly. In contrast, intravenous antibiotics are often administered in a clinical setting by healthcare professionals, which alleviates the burden of patient compliance regarding the timing and dosage of the medication.

On the other hand, the administration of intravenous antibiotics can indeed present challenges. For example, they can be difficult to administer due to the need for intravenous access, which may require the placement of a catheter or other devices. Additionally, they can prompt quick allergic reactions in some patients, presenting an immediate health risk. Moreover, improper administration or extravasation of the drug can lead to tissue necrosis, causing damage to surrounding tissues. Thus, the correct answer highlights that patient compliance is not a factor in the same way as the other options.